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Previous work in our laboratories has suggested that (+)-5'-nor-7-deazaaristeromycin (compound 1) may represent a prototype structure for a series of compounds with significant antitrypanosomal activities. To test this possibility, a series of derivatives of compound 1 with changes in the cyclopentyl substituents (compounds 3 to 10) have been studied. Although some growth activity was obtained with the L-like compound 5, related compounds 3 and 7 had little or no activity below 100 microM. D-like compounds 4 and 6 showed some activity at or below 100 microM, but the most interesting finding was that both the D- and L-like compounds having a methyl substituent on the 4' position were most active.
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C J Bacchi
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Medicinal chemistry (Shariqah (United Arab Emirates)),
K L Seley, and
S W Schneller, and
D Rattendi, and
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C J Bacchi
April 2012,
Tetrahedron letters,
K L Seley, and
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D Rattendi, and
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C J Bacchi
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Bioorganic & medicinal chemistry,
K L Seley, and
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C J Bacchi
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European journal of medicinal chemistry,
K L Seley, and
S W Schneller, and
D Rattendi, and
S Lane, and
C J Bacchi
May 1965,
Journal of medicinal chemistry,
K L Seley, and
S W Schneller, and
D Rattendi, and
S Lane, and
C J Bacchi
January 1991,
The Journal of antibiotics,
