Biomaterial Database

Stem cell factor and hematopoiesis. 1997

V C Broudy

Department of Medicine, University of Washington, Seattle 98195-7710, USA.

UI	MeSH Term	Description	Entries
D008407	Mast Cells	Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.	Basophils, Tissue,Basophil, Tissue,Cell, Mast,Cells, Mast,Mast Cell,Tissue Basophil,Tissue Basophils
D008958	Models, Molecular	Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.	Molecular Models,Model, Molecular,Molecular Model
D006410	Hematopoiesis	The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).	Hematopoiesis, Medullary,Haematopoiesis,Medullary Hematopoiesis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D019009	Proto-Oncogene Proteins c-kit	A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.	Antigens, CD117,CD117 Antigens,Receptor, Stem Cell Factor,Stem Cell Factor Receptor,c-kit Protein,c-kit Receptor,kit Proto-Oncogene Protein,p145(c-kit),CD117 Antigen,Proto-Oncogene Protein c-kit,Proto-Oncogene Protein kit,SCF Receptor,p145 c-kit,p145c-kit,Proto Oncogene Protein c kit,Proto Oncogene Protein kit,Proto Oncogene Proteins c kit,Proto-Oncogene Protein, kit,c kit Protein,c kit Receptor,c-kit, Proto-Oncogene Protein,c-kit, Proto-Oncogene Proteins,c-kit, p145,kit Proto Oncogene Protein,p145 c kit,p145c kit
D019089	Stem Cell Factor	A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.	Mast Cell Growth Factor,Steel Factor,c-kit Ligand,kit Ligand,c kit Ligand