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Studies on endogenous inhibitors obtained from supernatant fluids of rat hepatocytes indicated that the supernatant arrests the normal cell cycle at two points, namely, before the beginning of the S phase and at the onset of metaphase when assayed in regenerating liver cells in situ. The specificity of this (these) inhibitory substance(s) was evidenced by the finding that no inhibition of cell division was observed in situ in tongue, intestine, or kidneys of animals injected with concentrations of the hepatocyte supernatant that inhibited cell division in regenerating liver. When higher concentrations of the inhibitor-containing supernatant were used, only the tongue epithelial cells were affected in addition to the regenerating liver cells.
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
July 1975,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
June 1979,
Journal of the National Cancer Institute,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
May 1985,
Endocrinology,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
February 1965,
The Journal of surgical research,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
January 1979,
Fukushima journal of medical science,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
October 1982,
Revista espanola de las enfermedades del aparato digestivo,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
January 1963,
The Journal of laboratory and clinical medicine,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
May 1964,
Cancer research,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
October 1971,
Archives internationales de physiologie et de biochimie,
J Lavigne, and
M Lalanne, and
J P Thompson, and
A Simard
November 1965,
Cancer research,
