BIOMAT Database Logo BIOMAT Database Logo

Hibernation-induction trigger. II. In vitro effects of prairie dog plasma albumin on mouse vas deferens contractility. 1997

D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Department of Biology, Wheaton College, IL 60187, USA. david.s.bruce@wheaton.edu

Involvement of opioid molecules in hibernation is well established, with the delta opioid receptor implicated in hibernation induction. Previous studies have shown that plasma albumin fractions (PAFs) from hibernating mammals contain an uncharacterized ligand called "hibernation-induction trigger" (HIT), which causes inhibition of induced contractility in the guinea pig ileum (GPI). In part I of this study, we described effects of PAF from two species of prairie dogs on induced contractility of the GPI. In the present study (part II), we examine the response of the mouse vas deferens (MVD), which is populated with the delta receptor subtype, to increasing concentrations of PAF from the white-tailed prairie dog (WT) and the black-tailed prairie dog (BT). Dose-response curves of lyophilized PAF yielded IC50 values (mg) (mean dose that inhibits contractility to 50% of control) of 11.0 for summer WT, 10.6 for hibernating WT, 9.4 for summer BT, 12.2 for winter active BT, and 4.7 for winter hibernating BT. These results suggest that delta opioid (HIT) is present in both species throughout the calendar year and that the induction of hibernation may involve not only levels of opioid but also dynamic interactions between endogenous opioid and its receptors.

UI MeSH Term Description Entries
D007082 Ileum The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D008297 Male Males
D009119 Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009130 Muscle, Smooth Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed) Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D009197 Myenteric Plexus One of two ganglionated neural networks which together form the ENTERIC NERVOUS SYSTEM. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility. (From FASEB J 1989;3:127-38) Auerbach's Plexus,Auerbach Plexus,Auerbachs Plexus,Plexus, Auerbach's,Plexus, Myenteric
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006605 Hibernation The dormant state in which some warm-blooded animal species pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs. Hibernation, Artificial,Induced Hibernation,Artificial Hibernation,Artificial Hibernations,Hibernation, Induced,Hibernations,Induced Hibernations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012589 Sciuridae A family of the order Rodentia which contains 49 genera. Some of the more common genera are MARMOTA, which includes the marmot and woodchuck; Sciurus, the gray squirrel, S. carolinensis, and the fox squirrel, S. niger; Tamias, the eastern and western chipmunk; and Tamiasciurus, the red squirrel. The flying squirrels, except the scaly-tailed Anomaluridae, also belong to this family. Chipmunks,Citellus,Eutamias,Prairie Dogs,Spermophilus,Squirrels,Susliks,Tamias,Chipmunk,Dog, Prairie,Dogs, Prairie,Prairie Dog,Squirrel,Suslik
D012709 Serum Albumin A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules. Plasma Albumin,Albumin, Serum

Related Publications

D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Hibernation-induction trigger. I. Opioid-like effects of prairie dog plasma albumin on induced contractility of guinea pig ileum.
November 1997, Pharmacology, biochemistry, and behavior,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Gonadal hormones and the contractility in vitro of the vas deferens of the dog.
May 1947, Endocrinology,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Opioids and hibernation. II. Effects of kappa opioid U69593 on induction of hibernation in summer-active ground squirrels by "hibernation induction trigger" (HIT).
November 1987, Life sciences,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Effects of vas deferens clipping on the testicular function in dog.
January 1979, The Indian journal of medical research,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
[Effects of d-isocorydine on the mouse vas deferens].
May 1986, Zhongguo yao li xue bao = Acta pharmacologica Sinica,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Effects of hypophysectomy on purinergic and noradrenergic contractility of the rat vas deferens.
August 1996, Journal of autonomic pharmacology,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Multiple effects of sibutramine on ejaculation and on vas deferens and seminal vesicle contractility.
September 2009, Toxicology and applied pharmacology,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
Effects of veratrine and paeoniflorin on isolated mouse vas deferens.
May 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
The effect of sympathomimetic drugs on contractility of the vas deferens in vitro and in vivo.
July 1979, Journal of reproduction and fertility,
D S Bruce, and D E Cox, and S K Crane, and M L Denholm, and R J Dhyanchand, and M J Hampl, and J A Kary, and A S Krober, and P R Oeltgen, and N D Horton, and H J Harlow
In vitro androgenic induction of a major protein in epithelial cell subcultures from mouse vas deferens.
November 1992, Endocrinology,
Copied contents to your clipboard!