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Haematin (ferriprotoporphyrin IX) is released from haemoglobin during its degradation in the malarial parasites' food vacuole and is detoxified by its polymerization into a form of beta-haematin called haemozoin, or malarial pigment. This process is protein independent in vitro. Quinoline antimalarial blood schizonticides accumulate in the food vacuole and may inhibit haematin polymerization by binding to haematin and preventing its incorporation into the growing haemozoin chain. Drug resistance to quinolines is thought to be due to reduced accumulation of the drug in the food vacuole. As some quinolines overcome this resistance, quinolines, as a class, remain a potential source of future antimalarial drugs.
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
April 1999,
The Biochemical journal,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
August 1996,
Biochemical pharmacology,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
March 2002,
Biochemical pharmacology,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
January 1969,
Journal of medicinal chemistry,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
April 1954,
The Biochemical journal,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
August 1950,
The Biochemical journal,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
July 1948,
Nature,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
November 1995,
Nature,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
February 1997,
International journal for parasitology,
R G Ridley, and
A Dorn, and
S R Vippagunta, and
J L Vennerstrom
November 2010,
European journal of medicinal chemistry,
