-transparent.png){kind=logo}
We examined the hemodynamic effects of 1,1,1-trichloroethane (TCE) inhalation in anesthetized dogs in acute inhalation experiments. Six adult mongrel dogs with spontaneous respiration were intubated, connected to a one-way valve. TCE was delivered by the tubular system connected to a 30-liter tedlar bag reservoir filled with 1 v/v% of TCE. After TCE inhalation, the animals revealed a significant decrease in systemic arterial pressure following a decrease in systemic vascular resistance. Pulmonary arterial pressure, pulmonary vascular resistance and right cardiac work increased significantly. These changes were compatible with clinical manifestations of TCE intoxication in human beings. In conclusion, inhalation of TCE may not only decrease peripheral vascular resistance, but also induce transient disturbance of pulmonary blood flow with subsequent pressure overloading in the right ventricle.
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
June 1997,
Forensic science international,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
March 1984,
Sangyo igaku. Japanese journal of industrial health,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
January 1996,
International archives of occupational and environmental health,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
September 1986,
Sangyo igaku. Japanese journal of industrial health,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
March 1987,
British medical journal (Clinical research ed.),
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
May 1985,
Sangyo igaku. Japanese journal of industrial health,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
April 1974,
Archives of environmental health,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
April 2013,
Inhalation toxicology,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
January 1999,
IARC monographs on the evaluation of carcinogenic risks to humans,
N Aoki, and
K Soma, and
H Katagiri, and
Y Aizawa, and
T Kadowaki, and
T Ohwada
October 1979,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
