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The present study has employed in vitro autoradiography to study the distribution and density of [3H]zolpidem binding sites, which are regarded as an index of ethanol-sensitive gamma-aminobutyric acid (GABA)A receptors, in the brains of alcohol-preferring Fawn-Hooded (FH) rats compared to non-alcohol preferring Wistar-Kyoto (WKY) rats. Binding of [3H]zolpidem showed a similar distribution profile in both rat strains examined and included cerebellum, globus pallidus, nucleus of the solitary tract and a number of midbrain/hindbrain nuclei. Densitometric quantitation of binding revealed that FH rats possessed a significantly higher density of [3H]zolpidem binding compared to WKY rats in cortical regions, substantia nigra pars reticulata and the ventral pallidum. These data indicate that FH rats may have an increased number of ethanol-sensitive GABA(A) receptors in regions intimately involved in reward processes, and may partially explain the alcohol-seeking nature of the FH rat.
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
January 1999,
Polish journal of pharmacology,
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
April 1998,
Alcohol (Fayetteville, N.Y.),
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
April 1994,
European journal of pharmacology,
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
May 1999,
Alcohol (Fayetteville, N.Y.),
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
May 2007,
Neuroscience,
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
April 1987,
Experientia,
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
July 2003,
Alcoholism, clinical and experimental research,
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
February 1994,
The Journal of pharmacology and experimental therapeutics,
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
June 1998,
Pharmacology, biochemistry, and behavior,
F Chen, and
A Rezvani, and
B Jarrott, and
A J Lawrence
August 1995,
Alcoholism, clinical and experimental research,
