Biomaterial Database

[Molecular biology of human herpesvirus 6: DNA replication and trans-activator genes]. 1998

N Inoue

Dept. Medicine, Univ. Washington.

HHV-6 genes and their functions that are unique and different from those of HCMV are summarized. HHV-6 encodes a HSV-1 UL9 homolog that is an origin-binding protein (OBP) essential for HSV-1 DNA replication, although HCMV has no clear homolog. The HHV-6 OBP binds to sequences with similarity to alpha-herpesvirus replication origin that lie within a genomic segment serving as an origin in transient assays. Consensus sequence for OBP binding, protein domain analyses and a model for OBP-origin interactions are described. HHV-6 encodes an AAV-2 rep homolog. Its transcript is expressed at low mRNA levels as a spliced transcript. The gene product suppresses both transformation by H.ras and transcription by HIV-1 promoters. HHV-6 specific transactivator gene DR7 exhibits malignant transforming activity and its protein binds to p53. Studies on IE-A locus and an HCMV UL69 homolog are also discussed.

UI	MeSH Term	Description	Entries
D004261	DNA Replication	The process by which a DNA molecule is duplicated.	Autonomous Replication,Replication, Autonomous,Autonomous Replications,DNA Replications,Replication, DNA,Replications, Autonomous,Replications, DNA
D004268	DNA-Binding Proteins	Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.	DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D004279	DNA, Viral	Deoxyribonucleic acid that makes up the genetic material of viruses.	Viral DNA
D005814	Genes, Viral	The functional hereditary units of VIRUSES.	Viral Genes,Gene, Viral,Viral Gene
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001483	Base Sequence	The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.	DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D014764	Viral Proteins	Proteins found in any species of virus.	Gene Products, Viral,Viral Gene Products,Viral Gene Proteins,Viral Protein,Protein, Viral,Proteins, Viral
D014779	Virus Replication	The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.	Viral Replication,Replication, Viral,Replication, Virus,Replications, Viral,Replications, Virus,Viral Replications,Virus Replications
D015534	Trans-Activators	Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.	Nuclear Trans-Acting Factor,Trans-Acting Factors,Trans-Acting Factor,Trans-Activator,Transactivator,Transactivators,Factor, Nuclear Trans-Acting,Factor, Trans-Acting,Factors, Trans-Acting,Nuclear Trans Acting Factor,Trans Acting Factor,Trans Acting Factors,Trans Activator,Trans Activators,Trans-Acting Factor, Nuclear
D015654	Herpesvirus 6, Human	Members of the ROSEOLOVIRUS genus of the Betaherpesvirales subfamily isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter the activity of NK CELLS. HHV-6; (HBLV) antibodies are elevated in patients with AIDS; SJOGREN'S SYNDROME; SARCOIDOSIS; CHRONIC FATIGUE SYNDROME, and certain malignancies. HHV-6A is the most common cause of EXANTHEMA SUBITUM and has been implicated in encephalitis. When HHV-6 integrates into the host genome it is referred to as ciHVH-6. When such VIRUS INTEGRATION occurs into the germline it is referred to as iciHHV-6.	HBLV,Herpesvirus 6A, Human,Herpesvirus 6B, Human,Human B-Lymphotropic Virus,Chromosomally Integrated Human Herpesvirus 6,Chromosomally Integrated Human Herpesvirus 6A,Chromosomally Integrated Human Herpesvirus 6B,HHV-6,HHV-6A,HHV-6B,HHV6,HHV6A,HHV6B,Human Herpesvirus 6,Human betaherpesvirus 6,Human betaherpesvirus 6A,Human betaherpesvirus 6B,Inherited Chromosomally Integrated Human Herpesvirus 6,Inherited Chromosomally Integrated Human Herpesvirus 6A,Inherited Chromosomally Integrated Human Herpesvirus 6B,ciHHV-6,ciHHV-6A,ciHHV-6B,ciHHV6,ciHHV6A,ciHHV6B,iciHHV-6,iciHHV-6A,iciHHV-6B,iciHHV6,iciHHV6A,iciHHV6B,B-Lymphotropic Virus, Human,B-Lymphotropic Viruses, Human,Human B Lymphotropic Virus,Human B-Lymphotropic Viruses,Human Herpesvirus 6A,Human Herpesvirus 6B,Human betaherpesvirus 6s