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Two dietary soybean isoflavones, genistein and daidzein, were studied for the inhibition of lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. The isoflavone genistein at 200 mumol/kg body wt significantly inhibited (53.6%, p < 0.001) lung tumor nodule formation. The lung collagen hydroxyproline content and the serum sialic acid level, a marker of metastasis, were also significantly lower in these animals than in untreated tumor-bearing animals. Genistein treatment also increased the life span of the tumor-bearing animals (47.7%, p < 0.001). The isoflavone daidzein had no significant effect on the reduction of lung metastasis induced by B16F-10 melanoma cells.
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
January 2002,
Clinical & experimental metastasis,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
October 2011,
Canadian journal of physiology and pharmacology,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
June 2007,
Integrative cancer therapies,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
February 2004,
Phytotherapy research : PTR,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
January 2013,
Integrative cancer therapies,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
September 2003,
Journal of experimental & clinical cancer research : CR,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
June 2003,
Fitoterapia,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
January 2010,
Asian Pacific journal of cancer prevention : APJCP,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
June 2004,
Toxicology letters,
L G Menon, and
R Kuttan, and
M G Nair, and
Y C Chang, and
G Kuttan
June 1997,
Journal of experimental & clinical cancer research : CR,
