-transparent.png){kind=logo}
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel situated on the apical membrane of epithelial cells. Our recent studies of purified, reconstituted CFTR revealed that it also functions as an ATPase and that there may be coupling between ATP hydrolysis and channel gating. Both the ATP turnover rate and channel gating are slow, in the range of 0.2 to 1 s(-1), and both activities are suppressed in a disease-causing mutation situated in a putative nucleotide binding motif. Our future studies using purified protein will be directed toward understanding the structural basis and mechanism for coupling between hydrolysis and channel function.
Related Publications
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
March 1994,
Neuron,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
July 2000,
Proceedings of the National Academy of Sciences of the United States of America,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
July 1995,
Cell,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
January 1999,
Physiological reviews,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
May 2013,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
February 2010,
Proceedings of the National Academy of Sciences of the United States of America,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
April 2005,
The Journal of general physiology,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
March 1995,
The Journal of general physiology,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
August 1998,
Acta physiologica Scandinavica. Supplementum,
C E Bear, and
C Li, and
K Galley, and
Y Wang, and
E Garami, and
M Ramjeesingh
May 2001,
Biochemistry,
