Biomaterial Database

Lower oesophageal sphincter tone increases after induction of anaesthesia in pigs with full stomach. 1998

J P Tournadre, and M Barclay, and P Boulétreau, and D Chassard

Service d'Anesthésie-Réanimation Hôpital de l'Hôtel-Dieu, Lyon, France. jptourna@univ-lyon1.fr

OBJECTIVE The lower oesophageal sphincter (LOS) is the man mechanism that prevents gastro-oesophageal regurgitation during anaesthesia. The aim of this study was to assess the effect on lower oesophageal sphincter pressure (LOSP) of rapid sequence induction in pigs with full stomachs. METHODS Lower oesophageal sphincter pressure and oesophageal barrier pressure (BrP = LOSP minus gastric pressure) were measured using a water-perfused manometric catheter method in 12 pigs after gastric filling with 500 ml of liquid nutrient mixture. Six pigs were randomly allocated to receive 5 mg.kg-1 propofol and 3 mg.kg-1 succinylcholine i.v. and six pigs received 8 mg.kg-1 thiopentone and 3 mg.kg-1 succinylcholine i.v. RESULTS After induction, mean LOSP increased during the period with fasciculations from 19 +/- 4 mmHg to 28 +/- 5 mmHg in the propofol-succinylcholine group and from 23 +/- 6 mmHg to 36 +/- 7 mmHg in the thiopentone-succinylcholine group. The LOSP remained elevated after the fasciculations. LOSP and BrP were not different between the groups. CONCLUSIONS Induction of anaesthesia with propofol-succinylcholine or thiopentone-succinylcholine increases LOSP and, consequently, BrP in pigs with a full stomach. This increase begins before fasciculations and remains elevated for the period when intubation would occur.

UI	MeSH Term	Description	Entries
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D004943	Esophagogastric Junction	The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.	Gastroesophageal Junction,Gastroesophageal Junctions,Junction, Esophagogastric,Junction, Gastroesophageal,Junctions, Gastroesophageal
D000758	Anesthesia	A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013390	Succinylcholine	A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.	Succinyldicholine,Suxamethonium,Anectine,Celocurine,Dicholine Succinate,Ditilin,Listenon,Lysthenon,Myorelaxin,Quelicin,Succicuran,Succinylcholine Chloride,Succinylcholine Dibromide,Succinylcholine Dichloride,Succinylcholine Dichloride, Di-H2O,Succinylcholine Diiodide,Succinylcholine Diperchlorate,Succinylcholine Iodide,Suxamethonium Bromide,Suxamethonium Chloride,Bromide, Suxamethonium,Dibromide, Succinylcholine,Dichloride, Succinylcholine,Diiodide, Succinylcholine,Diperchlorate, Succinylcholine,Succinate, Dicholine,Succinylcholine Dichloride, Di H2O
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013874	Thiopental	A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration.	Penthiobarbital,Thiomebumal,Thiopentobarbital,Bomathal,Nesdonal,Pentothal,Pentothal Sodico,Sodipental,Thionembutal,Thiopental Nycomed,Thiopental Sodium,Thiopentone,Tiobarbital Braun,Trapanal
D015742	Propofol	An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.	Disoprofol,2,6-Bis(1-methylethyl)phenol,2,6-Diisopropylphenol,Aquafol,Diprivan,Disoprivan,Fresofol,ICI-35,868,ICI-35868,Ivofol,Propofol Abbott,Propofol Fresenius,Propofol MCT,Propofol Rovi,Propofol-Lipuro,Recofol,2,6 Diisopropylphenol,ICI 35,868,ICI 35868,ICI35,868,ICI35868