-transparent.png){kind=logo}
Following exposure to an aerosol of 0.1% (.005 M) cadmium chloride, rat lungs were examined at 6 hours and 1, 2, 3, 4, 7, and 10 days. By light microscopy, damage was multifocal and centered about respiratory bronchioles. Ultrastructurally, there was Type 1 cell edema with frequent loss of surface plasma membranes during the first 24 hours. After 2 days, the number of Type 2 cells had markedly increased, and by 3 days the damaged alveoli were lined by plump cuboidal cells closely resembling Type 2 cells. By 4 days, these cells were flatter, the change being more marked by 7 days; by 10 days, the cells had regained the appearance of Type 1 cells through loss of osmiophilic bodies and superficial microvilli. We conclude that CdCl2 damages Type 1 cells, which are then replaced by proliferation of Type 2 cells. These cells lose their osmiophilic bodies and flatten out to replace the lost Type 1 cells, the process being almost complete by 10 days after the injury. This pattern resembles the injury caused by NO2, O3, and O2.
R H Strauss, and
K C Palmer, and
J A Hayes
January 1978,
The American journal of pathology,
R H Strauss, and
K C Palmer, and
J A Hayes
July 1979,
The Journal of pathology,
R H Strauss, and
K C Palmer, and
J A Hayes
January 2015,
Experimental biology and medicine (Maywood, N.J.),
R H Strauss, and
K C Palmer, and
J A Hayes
January 1999,
Canadian respiratory journal,
R H Strauss, and
K C Palmer, and
J A Hayes
August 1975,
The American review of respiratory disease,
R H Strauss, and
K C Palmer, and
J A Hayes
June 2014,
Cell death & disease,
R H Strauss, and
K C Palmer, and
J A Hayes
March 2000,
American journal of respiratory and critical care medicine,
R H Strauss, and
K C Palmer, and
J A Hayes
December 2003,
Annals of the New York Academy of Sciences,
R H Strauss, and
K C Palmer, and
J A Hayes
February 1976,
The American review of respiratory disease,
R H Strauss, and
K C Palmer, and
J A Hayes
November 2020,
International immunopharmacology,
