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X-ray induced mutation to 6-thioguanine (6TG)-resistance was studied in early passage cultures of human diploid fibroblasts. The appearance of phenotypic induced mutants in irradiated cell populations was linearly related to the number of post-irradiation cell doublings and to the duration of the growth period prior to mutant selection; the maximum yield of X-ray induced mutants was observed when cells surviving radiation had completed 3--4 douplings (6--7 days growth) in non-selective medium. The maximum induced mutation frequency was linearly related to X-ray dose and the mutation rate was estimated to be 3.1-10(-7) mutations per viable cell per rad. The data obtained for X-ray induced mutations in cultured human diploid fibroblasts were compared with (a) similar experimental data obtained with established cell cultures and (b) with theoretical predictions of X-ray mutation rates in human germ cells.
R Cox, and
W K Masson
May 1973,
Mutation research,
R Cox, and
W K Masson
April 1978,
Mutation research,
R Cox, and
W K Masson
February 2002,
Mutation research,
R Cox, and
W K Masson
January 1983,
Mutation research,
R Cox, and
W K Masson
January 1987,
Mutation research,
R Cox, and
W K Masson
March 1988,
Photochemistry and photobiology,
R Cox, and
W K Masson
January 1992,
Environmental and molecular mutagenesis,
R Cox, and
W K Masson
July 1984,
Photochemistry and photobiology,
R Cox, and
W K Masson
January 1996,
Radiation research,
R Cox, and
W K Masson
September 1984,
Cancer research,
