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The effect of 2-deoxy-D-glucose tetraacetate upon glucose-stimulated insulin release was explored in pancreatic islets from either normal or hereditary diabetic rats. At a high concentration (10 mM), it decreased the secretory response to D-glucose, such an inhibitory effect being more marked in the case of the alpha- than beta-anomer of the ester. At lower concentrations (0.19 to 1.7 mM), however, 2-deoxy-D-glucose tetraacetate augmented insulin secretion evoked by 8.3 mM D-glucose, with again a preference for the alpha-anomer of the ester. In relative terms, such an enhancing action was more marked in Goto-Kakizaki than normal rats. Hence, it is proposed that selected esters of non-nutrient carbohydrates could be used as insulinotropic tools in the treatment of non-insulin-dependent diabetes mellitus.
W J Malaisse, and
L E Flores, and
M M Kadiata
February 1998,
International journal of molecular medicine,
W J Malaisse, and
L E Flores, and
M M Kadiata
January 2000,
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W J Malaisse, and
L E Flores, and
M M Kadiata
March 1998,
Cancer letters,
W J Malaisse, and
L E Flores, and
M M Kadiata
January 1998,
Oncology reports,
W J Malaisse, and
L E Flores, and
M M Kadiata
May 1982,
The American journal of physiology,
W J Malaisse, and
L E Flores, and
M M Kadiata
January 1973,
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W J Malaisse, and
L E Flores, and
M M Kadiata
April 1983,
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W J Malaisse, and
L E Flores, and
M M Kadiata
November 1972,
Annals of surgery,
W J Malaisse, and
L E Flores, and
M M Kadiata
June 1998,
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W J Malaisse, and
L E Flores, and
M M Kadiata
February 2000,
International journal of pancreatology : official journal of the International Association of Pancreatology,
