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A population of individuals potentially at risk for psychiatric disorders was identified by screening 375 college student volunteers for low platelet monoamine oxidase (MAO) activity levels. The lower and upper 10 per cent in MAO activity were interviewed and family history data were obtained. Low-MAO probands reported more frequent psychiatric or psychological counseling and problems with the law. Families of low MAO probands had an eightfold increase in the incidence of suicide or suicide attempts over those of high-MAO probands. This suggests that reduced MAO levels, reported previously in patients with affective disorders and chronic schizophrenia, may predict a vulnerability to psychiatric disorder.
M S Buchsbaum, and
R D Coursey, and
D L Murphy
April 1979,
Biological psychiatry,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
January 1981,
Archiv fur Psychiatrie und Nervenkrankheiten,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
January 1976,
Schizophrenia bulletin,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
December 1980,
Psychiatry research,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
December 1981,
Life sciences,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
March 1987,
Psychiatry research,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
December 1994,
Acta psychiatrica Scandinavica,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
June 1977,
Medical biology,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
October 1978,
Life sciences,
M S Buchsbaum, and
R D Coursey, and
D L Murphy
December 1989,
Psychiatry research,
