-transparent.png){kind=logo}
Mast cells located in connective tissues are a potent source of vasoactive and inflammatory mediators, such as cytokines. They accumulate in tissues in a wide variety of diseases where their function in most cases in unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) (from 25.2 to 29.9%), and histamine (from 22.50 to 43.49%), compared to untreated cells (control). When IL-IRA-treated and -untreated RBLC were stimulated with a secretagogue (anti-IgE), no difference was found in the percent of 5HT and histamine release. The present studies describe an additional biological activity of IL-1RA, inhibiting histamine and 5HT spontaneous release from RBLC cultures.
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
January 1989,
Dermatologica,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
November 2004,
Biochemical and biophysical research communications,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
April 1994,
Biochimica et biophysica acta,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
January 2009,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
August 2000,
Biochemical and biophysical research communications,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
March 1994,
Biochimica et biophysica acta,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
January 1997,
Allergy,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
March 1992,
Japanese journal of pharmacology,
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
July 2006,
Journal of immunology (Baltimore, Md. : 1950),
P Conti, and
R C Barbacane, and
M Trakatellis, and
F C Placido, and
I Cataldo, and
M Reale
November 1992,
Molecular immunology,
