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Sera of 103 carriers of hepatitis B surface antigen were assayed for e-antigen and anti-e. Twenty-four were e-antigen-positive, 31 anti-e-positive, and 48 had neither detectable (e-negative). Aminotransferases were elevated in 75% of the e-antigen-positive carriers compared with 25% of e-negative carriers (P less than 0.001) and 13% of anti-e-positive carriers (P less than 0.001). Serum DNA polymerase activity was significantly higher in the e-antigen-positive carriers than in carriers without e-antigen. Dane particles were shown in 10 of 12 carriers with e-antigen, compared with one of 12 e-negative carriers (P less than 0.0003) and none of 12 anti-e-positive carriers (P less than 0.00003). These results suggest that ongoing hepatitis B viral replication is more active in e-antigen-positive carriers than in carriers without e-antigen, a finding that may help explain the high prevalence of chronic active hepatitis described in these individuals.
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
January 1975,
Intervirology,
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
January 1979,
Journal of medical virology,
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
March 1978,
The Journal of general virology,
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
January 1979,
La Ricerca in clinica e in laboratorio,
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
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J E Maynard
July 1976,
Journal of immunology (Baltimore, Md. : 1950),
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
June 1977,
The Journal of infectious diseases,
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
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Scandinavian journal of infectious diseases,
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
July 1976,
The Journal of infectious diseases,
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
December 1975,
Lancet (London, England),
S H Hindman, and
C R Gravelle, and
B L Murphy, and
D W Bradley, and
W R Budge, and
J E Maynard
January 1979,
Infection,
