-transparent.png){kind=logo}
3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 944 ordered water molecules and one sulfate ion. A comparison of the complementarity-determining regions of the Fab3A2 with those from the Protein Data Bank following the canonical structure method reveals a canonical main chain conformation. This antibody belongs to the canonical structure class (combination of canonical conformations of the complementarity determining loops) that shows a preference for haptens and not for peptides. However, the shape of the surface of the antigen binding loops resembles that of an anti-peptide antibody.
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
November 1992,
Proteins,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
September 1974,
Proceedings of the National Academy of Sciences of the United States of America,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
May 1983,
Journal of molecular biology,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
August 2005,
Acta crystallographica. Section D, Biological crystallography,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
January 1978,
The Journal of biological chemistry,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
September 2011,
Acta crystallographica. Section D, Biological crystallography,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
December 2002,
Acta crystallographica. Section D, Biological crystallography,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
November 2001,
Proteins,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
January 1987,
The Journal of biological chemistry,
C Fotinou, and
J Beauchamp, and
P Emsley, and
A deHaan, and
W J Schielen, and
E Bos, and
N W Isaacs
December 1973,
Proceedings of the National Academy of Sciences of the United States of America,
