Biomaterial Database

5-Methoxytryptophol rhythms in the chick pineal gland: effect of environmental lighting conditions. 1998

J B Zawilska, and D J Skene, and J Z Nowak

Department of Biogenic Amines, Polish Academy of Sciences, Lódź.

5-Methoxytryptophol (5-ML) rhythms were studied in the pineal glands of chicks which were adapted to three different lighting conditions: 12 h light: 12 h dark (LD), constant darkness (DD) and continuous light (LL). Pineal glands of chicks kept under LD conditions exhibited rhythmic fluctuations in 5-ML content. 5-ML levels were low (18+/-2 pg/pineal) during the dark phase of the cycle, they increased approximately 9-fold at the end of the dark phase, and remained high (176 +/-6 pg/pineal) throughout the light period. This pattern of 5-ML content also persisted under conditions of DD, indicating that the 5-ML rhythm is circadian in nature. This is the first evidence of circadian rhythmicity of 5-ML. Pineal 5-ML levels in chicks kept under LL were high (168+/-8 pg/pineal), but did not fluctuate in a rhythmic fashion. Under LD and DD, but not LL, the rhythm of 5-ML in the chick pineal is 180 degrees out of phase with the rhythm of melatonin biosynthesis, an observation suggesting that, at least in this species, the pineal production of these two hormones may be inversely correlated.

UI	MeSH Term	Description	Entries
D007211	Indoles	Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D008027	Light	That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.	Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D008029	Lighting	The illumination of an environment and the arrangement of lights to achieve an effect or optimal visibility. Its application is in domestic or in public settings and in medical and non-medical environments.	Illumination
D008297	Male		Males
D008550	Melatonin	A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
D010870	Pineal Gland	A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.	Epiphysis Cerebri,Pineal Body,Corpus Pineale,Gland, Pineal,Pineal Bodies,Pineal Glands
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003624	Darkness	The absence of light.	Darknesses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia