Biomaterial Database

Fatal outcome of transmission of hepatitis B from an e antigen negative surgeon. 1998

T Sundkvist, and G R Hamilton, and D Rimmer, and B G Evans, and C G Teo

Hillingdon Hospital. torbjorn@elcha.co.uk

Investigation of the death of a 77 year old woman from acute hepatitis B infection revealed that she had undergone orthopaedic surgery two and a half months earlier. The surgeon was found to be a hepatitis B surface antigen carrier, hepatitis B e antigen (HBeAg)negative, but with antibodies to HBeAg. Viruses from the surgeon and the patient were identical, apart from a single nucleotide substitution. Both had a precore mutation, which prevents expression of e antigen. A look back exercise was undertaken on the patients operated on by the surgeon during the previous year. The surgeon had performed exposure prone procedures on 253 patients, 188 of whom provided blood specimens. No HBsAg carriers were detected, and no serological markers of recent transmission were found.

UI	MeSH Term	Description	Entries
D009985	Orthopedics	A specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.
D002353	Carrier State	The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.	Asymptomatic Carrier State,Asymptomatic Infection Carrier,Inapparent Infection Carrier,Presymptomatic Carrier State,Presymptomatic Infection Carrier,Super-spreader Carrier,Superspreader Carrier,Asymptomatic Carrier States,Asymptomatic Infection Carriers,Carrier State, Asymptomatic,Carrier State, Presymptomatic,Carrier States,Carrier, Super-spreader,Carrier, Superspreader,Carriers, Super-spreader,Carriers, Superspreader,Inapparent Infection Carriers,Infection Carrier, Asymptomatic,Infection Carrier, Inapparent,Infection Carrier, Presymptomatic,Presymptomatic Carrier States,Presymptomatic Infection Carriers,Super spreader Carrier,Super-spreader Carriers,Superspreader Carriers
D005260	Female		Females
D006509	Hepatitis B	INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	Hepatitis B Virus Infection
D006513	Hepatitis B e Antigens	A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G.	HBeAg,Hepatitis B e Antigen,Hepatitis Be Antigen,e Antigen,e Antigens,HBe Ag-1,HBe Ag-2,Hepatitis Be Antigens,Antigen, Hepatitis Be,Antigen, e,Antigens, Hepatitis Be,Antigens, e,Be Antigen, Hepatitis,Be Antigens, Hepatitis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D017757	Infectious Disease Transmission, Professional-to-Patient	The transmission of infectious disease or pathogens from health professional or health care worker to patients. It includes transmission via direct or indirect exposure to bacterial, fungal, parasitic, or viral agents.	Disease Transmission, Professional-to-Patient,Transmission, Dentist-Patient,Transmission, Health Care Worker-Patient,Transmission, Physician-Patient,Transmission, Professional-to-Patient,Dentist-Patient Transmission,Disease Transmission, Professional-Patient,Health Care Worker-Patient Transmission,Healthcare Worker-Patient Transmission,Infection Transmission, Dentist-Patient,Infection Transmission, Physician-Patient,Infection Transmission, Professional-to-Patient,Pathogen Transmission, Professional-to-Patient,Physician-Patient Transmission,Professional-to-Patient Disease Transmission,Professional-to-Patient Transmission,Transmission, Healthcare Worker-Patient,Transmission, Professional-Patient,Dentist Patient Transmission,Dentist-Patient Infection Transmission,Disease Transmission, Professional Patient,Disease Transmission, Professional to Patient,Health Care Worker Patient Transmission,Healthcare Worker Patient Transmission,Infection Transmission, Dentist Patient,Infection Transmission, Physician Patient,Infection Transmission, Professional to Patient,Infection Transmissions, Professional-to-Patient,Infectious Disease Transmission, Professional to Patient,Pathogen Transmission, Professional to Patient,Pathogen Transmissions, Professional-to-Patient,Physician Patient Transmission,Physician-Patient Infection Transmission,Professional to Patient Disease Transmission,Professional to Patient Transmission,Professional-Patient Disease Transmission,Professional-Patient Transmission,Professional-to-Patient Infection Transmission,Professional-to-Patient Pathogen Transmission,Transmission, Dentist Patient,Transmission, Dentist-Patient Infection,Transmission, Health Care Worker Patient,Transmission, Healthcare Worker Patient,Transmission, Physician Patient,Transmission, Physician-Patient Infection,Transmission, Professional Patient,Transmission, Professional to Patient,Transmission, Professional-Patient Disease,Transmission, Professional-to-Patient Disease,Transmission, Professional-to-Patient Infection,Transmission, Professional-to-Patient Pathogen,Worker-Patient Transmission, Healthcare
D017809	Fatal Outcome	Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.	Fatal Outcomes,Outcome, Fatal,Outcomes, Fatal