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This review discusses the application of alpha particle-emitting radionuclides in targeted radioimmunotherapy. It will outline the production and chemistry of astatine-211, bismuth-212, lead-212, actinium-225, bismuth-213, fermium-255, radium-223 and terbium-149, which at present are the most promising alpha-emitting isotopes available for human clinical use. The selective cytotoxicity offered by alpha particle-emitting radioimmunoconstructs is due to the high linear energy transfer and short particle path length of these radionuclides. Based upon the pharmacokinetics of alpha particle-emitting radioimmunoconstructs, both stochastic and conventional dosimetric methodology is discussed, as is the preclinical and initial clinical use of these radionuclides conjugated to monoclonal antibodies for the treatment of human neoplasia.
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
May 2005,
European journal of nuclear medicine and molecular imaging,
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
January 2021,
Nuclear medicine and biology,
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
December 2004,
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...,
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
May 1988,
Science (New York, N.Y.),
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
January 1996,
Acta oncologica (Stockholm, Sweden),
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
June 2022,
Nuklearmedizin. Nuclear medicine,
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
August 1989,
Radiation research,
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
January 2024,
International journal of molecular sciences,
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
October 1974,
Analytical chemistry,
M R McDevitt, and
G Sgouros, and
R D Finn, and
J L Humm, and
J G Jurcic, and
S M Larson, and
D A Scheinberg
January 2014,
Immunotherapy,
