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Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An alpha-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared. Analysis in vitro showed that the radioimmunoconjugate was selectively cytotoxic to a Thy 1.2+ EL-4 murine tumor cell line. Approximately three bismuth-212-labeled immunoconjugates per target cell reduced the uptake of [3H]thymidine by the EL-4 target cells to background levels. Mice inoculated intraperitoneally with EL-4 cells were cured of their ascites after intraperitoneal injection of 150 microcuries of the antigen-specific radioimmunoconjugate, suggesting a possible role for such conjugates in intracavitary cancer therapy.
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
December 2004,
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
January 1996,
Acta oncologica (Stockholm, Sweden),
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
January 2014,
Immunotherapy,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
September 1998,
European journal of nuclear medicine,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
July 2011,
Current radiopharmaceuticals,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
May 2005,
European journal of nuclear medicine and molecular imaging,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
January 2013,
PloS one,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
November 2000,
Cancer research,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
September 1994,
Cancer research,
R M Macklis, and
B M Kinsey, and
A I Kassis, and
J L Ferrara, and
R W Atcher, and
J J Hines, and
C N Coleman, and
S J Adelstein, and
S J Burakoff
January 1986,
Proceedings of the National Academy of Sciences of the United States of America,
