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Mitogen-activated protein (MAP) kinases are critical for cell signaling goals such as cellular proliferation and induction of apoptosis. We examined whether MAP kinases, as a point of convergence for multiple extracellular stimuli, are activated in proliferative glomerulonephritis (GN) in vivo. Accelerated crescentic anti-glomerular basement membrane (GBM) GN was induced in rats preimmunized with rabbit IgG by administration of rabbit anti-rat GBM serum. Whole cortical tissue and isolated glomeruli were then subjected to kinase activity assays and Western blot analysis. Cortical activity of the archetypal MAP kinase, extracellular signal-regulated kinase (ERK), was increased significantly one, three, and seven days after induction of GN. In contrast, activation of MAP kinases with antiproliferative actions, stress-activated protein kinase, and p38 MAP kinase was detectable only in the early stages of proliferative GN (days one and three), implying that different MAP kinases serve distinct roles in the pathogenesis of GN.
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
February 2000,
Journal of the American Society of Nephrology : JASN,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
July 2003,
Journal of neuroimmunology,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
December 2002,
Acta neurologica Scandinavica,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
May 1996,
Journal of neurochemistry,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
June 2000,
Zeitschrift fur Gastroenterologie,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
January 2002,
Critical care medicine,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
January 2002,
Critical care medicine,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
May 2011,
Journal of thrombosis and thrombolysis,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
July 2000,
European journal of pharmacology,
D Bokemeyer, and
K E Guglielmi, and
A McGinty, and
A Sorokin, and
E A Lianos, and
M J Dunn
November 2003,
The Journal of surgical research,
