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The tissue renin-angiotensin systems (RAS) may have specific roles that complement those of the systemic RAS. In the adrenal, the tissue RAS has been implicated in the regulation of glomerulosa tissue growth and function, and in mediating the response of the tissue to stimulation by ACTH and potassium ions. To examine the role of the rat adrenal tissue RAS in its response to angiotensin II stimulation, adrenals were incubated either as bisected glands or as separated capsular glands (largely glomerulosa) under control conditions, or in the presence of the angiotensin-converting enzyme inhibitor captopril, or of angiotensin II, or both. Captopril inhibited the two different tissue preparations in different ways. In the capsular gland it inhibited basal aldosterone output, but facilitated its response to angiotensin II. In the bisected gland, captopril inhibited the response of aldosterone to angiotensin II. Other data suggest that one way in which captopril functions is by preventing the conversion of fasciculata-generated 18-hydroxydeoxycorticosterone (18-OH-DOC) to aldosterone in the glomerulosa. Immunolocalisation of 18-OH-DOC in perfused rat adrenal confirms that one function of angiotensin II is to mobilise tissue-sequestered 18-OH-DOC. The results illustrate the importance of tissue RAS in the synthesis of aldosterone and the response to angiotensin II.
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
January 1998,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
March 1990,
Acta endocrinologica,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
January 1995,
Advances in experimental medicine and biology,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
January 1998,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
January 1976,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
February 1972,
Endocrinology,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
March 1996,
The Journal of physiology,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
June 2009,
Hypertension research : official journal of the Japanese Society of Hypertension,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
November 1995,
Rinsho byori. The Japanese journal of clinical pathology,
G P Vinson, and
R Teja, and
M M Ho, and
J P Hinson, and
J R Puddefoot
June 1985,
The Anatomical record,
