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BACKGROUND The intestinal epithelium is covered by a continuous layer of mucus which is secreted by well differentiated epithelial cells. Disregulation of the expression of mucins has been reported to have possible implications in the neoplastic process which affects intestinal mucosae. It is well known that preneoplastic and neoplastic tissues can express fetal phenotypic characteristics. OBJECTIVE To assess whether the expression of mucin genes in the intestinal tract is linked to the stage of cellular differentiation and tissue development, by studying the expression of six mucin genes in human fetal small intestine and colon, and also adult tissues. METHODS In situ hybridisation was used to study mRNA expression of MUC2, MUC3, MUC4, MUC5B, MUC5AC, and MUC6 in 32 human embryos and fetuses (6.5-27 weeks gestation). Normal adult mucosae were used as controls. RESULTS Three mucin genes, MUC2, MUC4, and MUC5AC, were differently expressed in fetal intestine compared with expression in normal adults. CONCLUSIONS These differences in mucin gene expression suggest a possible regulatory role for these products in intestinal epithelial cell differentiation.
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
January 1992,
Pancreas,
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
January 1991,
The Journal of clinical investigation,
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
December 1998,
Rhinology,
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
October 2005,
Cancer research,
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
January 2004,
Investigative ophthalmology & visual science,
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
January 1995,
Human reproduction (Oxford, England),
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
September 2007,
The Laryngoscope,
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
January 1986,
Nature,
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
November 2006,
Human reproduction (Oxford, England),
M P Buisine, and
L Devisme, and
T C Savidge, and
C Gespach, and
B Gosselin, and
N Porchet, and
J P Aubert
February 2008,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
