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Antibody against a breast carcinoma antigen was present in patients with breast carcinoma and other cancer more often (P less than .05) than in normal women. The incidence of antibody in women with breast carcinoma correlated with the presence or absence of gross tumor, and the titer of antibody paralleled the clinical course. These results suggest importance of a host-immune response to breast carcinoma. Fifty-seven patients with stage II carcinoma of the breast were entered into a prospective randomized adjuvant chemoimmunotherapy program of cyclophosphamide, methotrexate, and fluorouracil, and BCG vaccine +/- an irradiated allogeneic tumor cell vaccine. After 24 months of study, metastases occurred in two patients (3.5%) and a new primary carcinoma developed in the contralateral breast in two others, for an overall treatment failure rate of 7%. Adjuvant chemoimmunotherapy can delay early recurrence. Long-term follow-up is needed to assess the significance of these results.
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
February 1977,
Journal of the Tennessee Medical Association,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
June 1978,
Cancer,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
January 1978,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
August 1984,
Journal of surgical oncology,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
January 1986,
Acta radiologica. Oncology,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
December 1976,
British medical journal,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
January 1982,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
January 1979,
Journal of surgical oncology,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
January 1982,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
F C Sparks, and
A G Wile, and
K P Ramming, and
H K Silver, and
R W Wolk, and
D L Morton
January 1984,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
