Biomaterial Database

[Studies of gamma-oryzanol (1). Effects on stress-induced ulcer]. 1976

K Itaya, and J Kiyonaga

In clinical trials, it is well known that gamma-oryzanol is effective against the syndromes of autonomic nervous unbalance and climacteric disorders. The authors studied the action of gamma-oryzanol on restraint, water-immersion stress ulcer under various conditions in rats. The drug, given 1 to 100 mg/kg s.c. daily for five days, reduced the ulcer index dose-dependently, and slightly prevented the rate of increase in serum level of 11-OHCS. These effects were observed in adrenalectomized as well as sham operated rats. It is likely that the antiulcerogenic action of gamma-oryzanol is due to participation of the autonomic nervous system, but not the hypophyseoadrenal axis.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010666	Phenylpropionates	Derivatives of 3-phenylpropionic acid, including its salts and esters.
D000315	Adrenalectomy	Excision of one or both adrenal glands. (From Dorland, 28th ed)	Adrenalectomies
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001337	Autonomic Agents	Agents affecting the function of, or mimicking the actions of, the autonomic nervous system and thereby having an effect on such processes as respiration, circulation, digestion, body temperature regulation, certain endocrine gland secretions, etc.	Autonomic Drugs,Autonomic Effect,Autonomic Effects,Agents, Autonomic,Drugs, Autonomic,Effect, Autonomic,Effects, Autonomic
D013276	Stomach Ulcer	Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	Gastric Ulcer,Gastric Ulcers,Stomach Ulcers,Ulcer, Gastric,Ulcer, Stomach,Ulcers, Gastric,Ulcers, Stomach
D013312	Stress, Physiological	The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.	Biotic Stress,Metabolic Stress,Physiological Stress,Abiotic Stress,Abiotic Stress Reaction,Abiotic Stress Response,Biological Stress,Metabolic Stress Response,Physiological Stress Reaction,Physiological Stress Reactivity,Physiological Stress Response,Abiotic Stress Reactions,Abiotic Stress Responses,Abiotic Stresses,Biological Stresses,Biotic Stresses,Metabolic Stress Responses,Metabolic Stresses,Physiological Stress Reactions,Physiological Stress Responses,Physiological Stresses,Reaction, Abiotic Stress,Reactions, Abiotic Stress,Response, Abiotic Stress,Response, Metabolic Stress,Stress Reaction, Physiological,Stress Response, Metabolic,Stress Response, Physiological,Stress, Abiotic,Stress, Biological,Stress, Biotic,Stress, Metabolic
D015062	11-Hydroxycorticosteroids	A group of corticosteroids bearing a hydroxy group at the 11-position.	11 Hydroxycorticosteroids
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus