Biomaterial Database

[Studies of gamma-oryzanol. (2) The antiulcerogenic action]. 1976

K Itaya, and J Kitonaga, and M Ishikawa

Investigations were performed in male Wistar rats to determine the effects of gamma-oryzanol on circadian rhythm of stress ulcer and on various kinds of experimental ulcers, and the modification of antiulcerogenic action of this drug when combined with the inhibitors or precursors of amine metabolism. Circadian rhythms were observed in stress ulceration with a peak at 2 : 00 p.m. and a reduction at 8 : 00 p.m. The inhibitory action of gamma-oryzanol was significant when stress was loaded for 6 hr from 2 : 00 a.m., 5 : 00 a.m., 11 : 00 a.m. or 2:00 p.m. An 8-day treatment with gamma-oryzanol, 100 mg/kg, s.c., showed a significant inhibition of fasting ulcer, while the 5-day pretreatment exerted slight effects on ulcers by pylorus-ligation or stress-atropine. A 10-day treatment with the same dose of gamma-oyzanol in acetic acid ulcers lowered the serum level of gastrin. Treatment with reserpine, alpha-MT or PCPA prior to stress loading abolished the anti-ulcer effect of gamma-oryzanol, 100 mg/kg, s.c. for 5 days in stress ulcer. Treatment with L-DOPA or 5-HTP revealed a tendency toward restoration of the anti-ulcer effect of gamma-oryzanol. It is suggested that the monoaminergic neuron system is involved in the anti-ulcer action of gamma-oryzanol.

UI	MeSH Term	Description	Entries
D007980	Levodopa	The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.	L-Dopa,3-Hydroxy-L-tyrosine,Dopaflex,Dopar,L-3,4-Dihydroxyphenylalanine,Larodopa,Levopa,3 Hydroxy L tyrosine,L 3,4 Dihydroxyphenylalanine,L Dopa
D008297	Male		Males
D010666	Phenylpropionates	Derivatives of 3-phenylpropionic acid, including its salts and esters.
D012110	Reserpine	An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.	Raunervil,Raupasil,Rausedil,Rausedyl,Serpasil,Serpivite,V-Serp,V Serp
D002395	Catecholamines	A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE.	Catecholamine,Sympathin,Sympathins
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D005215	Fasting	Abstaining from FOOD.	Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D006916	5-Hydroxytryptophan	The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.	5-HTP,Hydroxytryptophan,Oxitriptan,Oxytryptophan,Tryptophan, 5-Hydroxy-,5 Hydroxytryptophan,5-Hydroxy- Tryptophan,Tryptophan, 5 Hydroxy
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000897	Anti-Ulcer Agents	Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.	Anti-Ulcer Drugs,Agents, Anti-Ulcer,Anti Ulcer Agents,Anti Ulcer Drugs,Drugs, Anti-Ulcer