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[Transplacental blastomogenic effect of N-nitrosomethylurea in rats with constant estrus]. 1976

V A Aleksandrov, and V N Anisimov

As a result of transplacental exposure of rats of NMU in the dosage of 20 mg/Kg (intraperitoneally) on the 21st day of pregnancy tumors in the offspring developed in 6 to 16 females and in 10 of 17 males. In rats with persistent estrus, induced in sex mature females by their castration and one-moment autoimplantation of ovaries in the tail, tumour developed in 25 of 41 animals. In combination of transplacental effect of NMU and postnatal induction of persistent estrus in females neoplasms were recorded in 14 of 17 animals, the incidence of neoplasms of the nervous system and kidney observed only after transplacental NMU exposure of males being increased. Hormonalmetabolic shifts observed in rats with persistent estrus seemed to potentiate transplacental blastomogenic action of NMU.

UI MeSH Term Description Entries
D008297 Male Males
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D008770 Methylnitrosourea A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties. Nitrosomethylurea,N-Methyl-N-nitrosourea,NSC-23909,N Methyl N nitrosourea,NSC 23909,NSC23909
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D009607 Nitrosourea Compounds A class of compounds in which the core molecule is R-NO, where R is UREA. Compounds, Nitrosourea
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D004971 Estrus The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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