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The paper discusses the influence of deranged function of the thyroid (in postnatal period) on the transplacental carcinogenic effect of N-nitrosomethylurea (NMU) in albino noninbred rats. It was found that exogenous thyroxin-induced hyperthyroidism and thyroid function suppression either by long-term treatment with a thyreostatic agent--methylthiouracil (MTU) or thyroidectomy are followed by a lower frequency of, chiefly, nervous system tumors which are typical of NMU-induced transplacental carcinogenesis in rats. Moreover, transplacental treatment with NMU potentiated the carcinogenic effect of MTU on the thyroid. The latter manifested itself in a higher frequency of malignancies of the thyroid in animals exposed to a combined treatment with NMU (transplacentally) and MTU (postnatally) as compared with those given MTU only (postnatally).
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
July 1980,
Biulleten' eksperimental'noi biologii i meditsiny,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
January 1994,
Voprosy onkologii,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
January 1976,
Voprosy onkologii,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
December 1984,
Cancer letters,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
February 2001,
Cancer letters,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
January 1985,
Eksperimental'naia onkologiia,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
January 1988,
Journal of cancer research and clinical oncology,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
September 1986,
Cancer research,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
February 1995,
Mutation research,
I G Popovich, and
V A Aleksandrov, and
G A Blinova, and
N P Napalkov
February 1975,
Journal of the National Cancer Institute,
