BIOMAT Database Logo BIOMAT Database Logo

Regulation of T-helper cell responses to inhalant allergen during early childhood. 1999

C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
TVW Telethon Institute for Child Health Research, Perth, WA, Australia.

BACKGROUND Recent evidence suggests that preschool children manifest patterns of allergen-specific skin prick test (SPT) reactivity and in vitro T-cell cytokine production which are similar to that of either atopic or nonatopic adults. However, published studies on this age group involve small sample sizes and a restricted number of cytokines, usually in response to polyclonal stimuli. OBJECTIVE To elucidate the relationship between in vivo and in vitro immune responses to a major inhalant allergen house dust mite (HDM) in preschoolers. METHODS Peripheral blood mononuclear cells (PBMCs) from matched groups of HDM-SPT+ and SPT- 6-year-olds (n = 30 and 29, respectively) tested for PBMC responses to HDM, and cytokine production measured at both the protein and mRNA levels. Immunoglobulin (Ig) E and IgG subclass antibody titres were determined in serum. Interrelationships between in vitro and in vivo HDM responses were examined via multivariate analyses. RESULTS SPT reactivity to HDM was associated with in vitro production by putative T cells of interleukin (IL) -4, IL-5, IL-9, IL-10, IL-13 and low level IFNgamma, and with production in vivo of IgE and (all) IgG subclass antibodies; HDM responses in the SPT- group were restricted mainly to IL-10 and IFNgamma and very low levels of IL-4; IL-6 production from non-T-cell sources was common. The cytokine most associated with positive SPT responses was IL-9; SPT weal diameter correlated positively with IL-4, IL-5 and IL-13 and negatively with IL-10. CONCLUSIONS Detailed analysis of cytokine responses in this very young age group have the potential to uncover subtle relationships between in vivo and in vitro allergen reactivity which may be less clear in adults, in whom T-cell response patterns are modified via chronic stimulation. The present findings which suggest potentially important roles for IL-9 and IL-10 in the early phase of allergic disease, may be one such example.

UI MeSH Term Description Entries
D006967 Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. Allergy,Allergic Reaction,Allergic Reactions,Allergies,Hypersensitivities,Reaction, Allergic,Reactions, Allergic
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D008925 Mites Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants. Acarus,Mite
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004391 Dust Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed) House Dust,Housedust,Dust, House
D006023 Glycoproteins Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins. C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D006377 T-Lymphocytes, Helper-Inducer Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions. Helper Cell,Helper Cells,Helper T Cell,Helper-Inducer T-Lymphocytes,Inducer Cell,Inducer Cells,T-Cells, Helper-Inducer,T-Lymphocytes, Helper,T-Lymphocytes, Inducer,Helper T-Cells,Cell, Helper T,Cells, Helper T,Helper Inducer T Lymphocytes,Helper T Cells,Helper T-Cell,Helper T-Lymphocyte,Helper T-Lymphocytes,Helper-Inducer T-Cell,Helper-Inducer T-Cells,Helper-Inducer T-Lymphocyte,Inducer T-Lymphocyte,Inducer T-Lymphocytes,T Cell, Helper,T Cells, Helper,T Cells, Helper Inducer,T Lymphocytes, Helper,T Lymphocytes, Helper Inducer,T Lymphocytes, Inducer,T-Cell, Helper,T-Cell, Helper-Inducer,T-Cells, Helper,T-Lymphocyte, Helper,T-Lymphocyte, Helper-Inducer,T-Lymphocyte, Inducer
D006798 Housing Living facilities for humans. Family-Patient Lodging,Patient-Family Lodging,Family Patient Lodging,Family-Patient Lodgings,Lodging, Family-Patient,Lodging, Patient-Family,Lodgings, Family-Patient,Lodgings, Patient-Family,Patient Family Lodging,Patient-Family Lodgings

Related Publications

C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
Regulation of helper T cell responses to staphylococcal superantigens.
January 2001, European cytokine network,
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
The regulation of T follicular helper responses during infection.
June 2015, Current opinion in immunology,
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
T-cell responses during allergen-specific immunotherapy.
February 2012, Current opinion in allergy and clinical immunology,
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
Regulation of T helper cell responses during antigen presentation by norepinephrine-exposed endothelial cells.
May 2018, Immunology,
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
Inhibition of primary and recall allergen-specific T helper cell type 2-mediated responses by a T helper cell type 1 stimulus.
July 1997, Journal of immunology (Baltimore, Md. : 1950),
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
Up-regulation of murine neonatal T helper cell responses by accessory cell factors.
October 1994, Journal of immunology (Baltimore, Md. : 1950),
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
February 2020, Cell metabolism,
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
Decoy receptors in the regulation of T helper cell type 2 responses.
March 2003, The Journal of experimental medicine,
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
T cell regulation of antibody responses: an I-A-specific, autoreactive T cell collaborates with antigen-specific helper T cells to promote IgG responses.
February 1985, Journal of immunology (Baltimore, Md. : 1950),
C Macaubas, and P D Sly, and P Burton, and K Tiller, and A Yabuhara, and B J Holt, and T B Smallacombe, and G Kendall, and M C Jenmalm, and P G Holt
Analysis of T helper cell responses during infection with Leishmania amazonensis.
April 2002, The American journal of tropical medicine and hygiene,
Copied contents to your clipboard!