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Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents. 2004
Kenneth L Smith, and
Vicky C H Lai, and
Brett J Prigaro, and
Yili Ding, and
Esmir Gunic, and
Jean-Luc Girardet, and
Weidong Zhong, and
Zhi Hong, and
Stanley Lang, and
Haoyun An
Valeant Pharmaceuticals International, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA.
Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.
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