BIOMAT Database Logo BIOMAT Database Logo

Asymmetric synthesis of cyclopropyl-fused 2'-C-methylcarbanucleosides as potential anti-HCV agents. 2007

Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr

Novel 2'-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.

UI MeSH Term Description Entries
D007202 Indicators and Reagents Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499) Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D009705 Nucleosides Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Nucleoside,Nucleoside Analog,Nucleoside Analogs,Analog, Nucleoside,Analogs, Nucleoside
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D015195 Drug Design The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS, dosage analysis, or drug administration analysis. Computer-Aided Drug Design,Computerized Drug Design,Drug Modeling,Pharmaceutical Design,Computer Aided Drug Design,Computer-Aided Drug Designs,Computerized Drug Designs,Design, Pharmaceutical,Drug Design, Computer-Aided,Drug Design, Computerized,Drug Designs,Drug Modelings,Pharmaceutical Designs
D016174 Hepacivirus A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species. Hepatitis C virus,Hepatitis C-Like Viruses,Hepaciviruses,Hepatitis C Like Viruses,Hepatitis C viruses,Hepatitis C-Like Virus

Related Publications

Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
November 2011, Bioorganic & medicinal chemistry letters,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
June 2014, ACS medicinal chemistry letters,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Synthesis of 2'-fluoro and 2',4'-dimethyl pyrimidine C-nucleoside analogues as potential anti-HCV agents.
March 2010, Nucleosides, nucleotides & nucleic acids,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents.
July 2004, Bioorganic & medicinal chemistry letters,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Synthesis and in vitro activity evaluation of 2',3'-C-dimethyl carbocyclic nucleoside analogues as potential anti-HCV agents.
August 2009, Nucleosides, nucleotides & nucleic acids,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents.
July 2008, Archives of pharmacal research,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics.
October 2010, Organic letters,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Discovery of 3-Amino-2-Hydroxypropoxyisoflavone Derivatives as Potential Anti-HCV Agents.
November 2018, Molecules (Basel, Switzerland),
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.
November 2014, Bioorganic & medicinal chemistry letters,
Lak Shin Jeong, and Jeong A Lee, and Hea Ok Kim, and Dilip K Tosh, and Hyung Ryong Moon, and Seung-Jin Lee, and Kang Man Lee, and Yhun Y Sheen, and Moon Woo Chun
Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.
February 2007, Bioorganic chemistry,
Copied contents to your clipboard!