Development of Graves' disease after subacute thyroiditis: two unusual cases. 1992

S Fukata, and F Matsuzuka, and A Kobayashi, and K Hirai, and K Kuma, and M Sugawara
Kuma Hospital, Kobe, Japan.

This report describes two unusual cases of subacute thyroiditis from which Graves' disease with hyperthyroidism developed seven to eight years after complete recovery. The first case is a 45-year-old woman who developed hyperthyroidism seven years after recovering from subacute thyroiditis. This patient had a genetic predisposition to both subacute thyroiditis HLA-BW35 and Graves' disease (HLA-BW46). The second case is a 60-year-old woman who developed hyperthyroidism eight years after the episode of subacute thyroiditis; her HLA showed neither BW 35 nor BW 46. It has been reported that if hyperthyroidism is to develop following subacute thyroiditis it occurs within one year. Our observation indicates that it may occur seven or eight years later.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006111 Graves Disease A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013968 Thyroiditis, Subacute Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection. De Quervain Thyroiditis,Giant Cell Thyroiditis,Granulomatous Thyroiditis,Subacute Nonsuppurative Thyroiditis,Subacute Painful Thyroiditis,Cell Thyroiditides, Giant,Cell Thyroiditis, Giant,Giant Cell Thyroiditides,Granulomatous Thyroiditides,Nonsuppurative Thyroiditides, Subacute,Nonsuppurative Thyroiditis, Subacute,Painful Thyroiditides, Subacute,Painful Thyroiditis, Subacute,Subacute Nonsuppurative Thyroiditides,Subacute Painful Thyroiditides,Subacute Thyroiditides,Subacute Thyroiditis,Thyroiditides, Giant Cell,Thyroiditides, Granulomatous,Thyroiditides, Subacute,Thyroiditides, Subacute Nonsuppurative,Thyroiditides, Subacute Painful,Thyroiditis, De Quervain,Thyroiditis, Giant Cell,Thyroiditis, Granulomatous,Thyroiditis, Subacute Nonsuppurative,Thyroiditis, Subacute Painful
D015235 HLA-B Antigens Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes. Antigens, HLA-B,HLA-B Antigen,HLA-B,Antigen, HLA-B,Antigens, HLA B,HLA B Antigen,HLA B Antigens
D015797 HLA-B35 Antigen A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*35 allele family. HLA Class I Histocompatibility Antigen, B-35 alpha Chain,HLA-B35,Antigen, HLA-B35,HLA B35 Antigen,HLA Class I Histocompatibility Antigen, B 35 alpha Chain

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