Biomaterial Database

Relapse of Graves' disease after subacute thyroiditis. 1998

F Grunenberger, and M P Chenard, and J C Weber, and D Jaeck, and J L Schlienger

Service de Médecine Interne, Hôpital de Hautepierre, Centre Hospitalier et Universitaire de Strasbourg, France.

We report the case of a 46-year-old man whose Graves' disease relapsed 5 years after its first appearance. At the time of relapse thyrotropin (TSH) receptor antibodies were very high, as was radioactive uptake in the left lobe of the thyroid. After thyroidectomy, histological analysis of the specimen showed evidence of treated Graves' disease, and there were signs of subacute thyroiditis in the right lobe. The clinical and immunologic characteristics of this observation are discussed as well as the hypothesis explaining the succession of an inflammatory and autoimmune thyroid disease.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011989	Receptors, Thyrotropin	Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).	Receptors, Thyroid Stimulating Hormone,TSH Receptors,Thyroid Stimulating Hormone Receptors,Thyrotropin Receptors,LATS Receptors,Receptor, LATS Immunoglobulins,Receptors, LATS,Receptors, Long-Acting Thyroid Stimulator,Receptors, TSH,TSH Receptor,Thyroid Stimulating Hormone Receptor,Thyrotropin Receptor,Receptor, TSH,Receptor, Thyrotropin,Receptors, Long Acting Thyroid Stimulator
D012008	Recurrence	The return of a sign, symptom, or disease after a remission.	Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D006111	Graves Disease	A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).	Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001323	Autoantibodies	Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.	Autoantibody
D013965	Thyroidectomy	Surgical removal of the thyroid gland. (Dorland, 28th ed)	Thyroidectomies
D013968	Thyroiditis, Subacute	Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection.	De Quervain Thyroiditis,Giant Cell Thyroiditis,Granulomatous Thyroiditis,Subacute Nonsuppurative Thyroiditis,Subacute Painful Thyroiditis,Cell Thyroiditides, Giant,Cell Thyroiditis, Giant,Giant Cell Thyroiditides,Granulomatous Thyroiditides,Nonsuppurative Thyroiditides, Subacute,Nonsuppurative Thyroiditis, Subacute,Painful Thyroiditides, Subacute,Painful Thyroiditis, Subacute,Subacute Nonsuppurative Thyroiditides,Subacute Painful Thyroiditides,Subacute Thyroiditides,Subacute Thyroiditis,Thyroiditides, Giant Cell,Thyroiditides, Granulomatous,Thyroiditides, Subacute,Thyroiditides, Subacute Nonsuppurative,Thyroiditides, Subacute Painful,Thyroiditis, De Quervain,Thyroiditis, Giant Cell,Thyroiditis, Granulomatous,Thyroiditis, Subacute Nonsuppurative,Thyroiditis, Subacute Painful

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