Biomaterial Database

Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation. 2007

Hiroki Kumamoto, and Hiromichi Tanaka

School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. kumamoto@pharm.showa-u.ac.jp

An approach was developed for the synthesis of 5'-branched neplanocin A, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinyl-stannane system of the key synthetic intermediate (14) in the present study, was prepared by radical-mediated sulfur-extrusive stannylation.

UI	MeSH Term	Description	Entries
D009947	Organotin Compounds	Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.	Compounds, Organotin
D004791	Enzyme Inhibitors	Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.	Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D005609	Free Radicals	Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. Free radicals include reactive oxygen and nitrogen species (RONS). They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.	Free Radical
D000241	Adenosine	A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.	Adenocard,Adenoscan
D000998	Antiviral Agents	Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.	Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D013455	Sulfur	An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	Sulfur-16,Sulfur 16
D043383	Adenosylhomocysteinase	An enzyme which catalyzes the catabolism of S-ADENOSYLHOMOCYSTEINE to ADENOSINE and HOMOCYSTEINE. It may play a role in regulating the concentration of intracellular adenosylhomocysteine.	S-adenosylhomocysteine Hydrolase,S-adenosylhomocysteine Synthase,SAH Hydrolase,Hydrolase, S-adenosylhomocysteine,S adenosylhomocysteine Hydrolase,S adenosylhomocysteine Synthase