Synthesis of some new 2-(substituted-phenyl)-5-(N,N-diphenylaminomethyl)-1,3,4-oxadiazoles: a safer anti-inflammatory and analgesic agents. 2011

Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India.

A series of 2-(substituted-phenyl)-5-(N,N-diphenylaminomethyl)-1,3,4-oxadiazoles (3-15) were synthesized. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The percentage inhibition in edema at different time intervals indicated that compounds 8, 11, 12, 14 and 15 exhibited good anti-inflammatory potential. The results illustrate that 2-(2-acetoxyphenyl)-5-(N,N-diphenylaminomethyl)-1,3,4-oxadiazole (15) and 2-(3,4-dimethoxyphenyl)-5-(N,N-diphenylaminomethyl)-1,3,4-oxadiazole (12) showed best anti-inflammatory activity among the series tested. Furthermore, activity is higher in case of chloro substitution as compared to methyl substitution. The compounds synthesized were also evaluated for their ulcerogenic and lipid peroxidation action and showed superior GI safety profile along with reduction in lipid peroxidation as compared to that of ibuprofen.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D010069 Oxadiazoles Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms. Oxadiazole
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D010147 Pain Measurement Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies. Analgesia Tests,Analogue Pain Scale,Formalin Test,McGill Pain Questionnaire,Nociception Tests,Pain Assessment,Pain Intensity,Pain Severity,Tourniquet Pain Test,Visual Analogue Pain Scale,Analog Pain Scale,Assessment, Pain,McGill Pain Scale,Visual Analog Pain Scale,Analgesia Test,Analog Pain Scales,Analogue Pain Scales,Formalin Tests,Intensity, Pain,Measurement, Pain,Nociception Test,Pain Assessments,Pain Intensities,Pain Measurements,Pain Questionnaire, McGill,Pain Scale, Analog,Pain Scale, Analogue,Pain Scale, McGill,Pain Severities,Pain Test, Tourniquet,Questionnaire, McGill Pain,Scale, Analog Pain,Scale, Analogue Pain,Scale, McGill Pain,Severity, Pain,Test, Analgesia,Test, Formalin,Test, Nociception,Test, Tourniquet Pain,Tests, Nociception,Tourniquet Pain Tests
D010437 Peptic Ulcer Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS). Gastroduodenal Ulcer,Marginal Ulcer,Gastroduodenal Ulcers,Marginal Ulcers,Peptic Ulcers,Ulcer, Gastroduodenal,Ulcer, Marginal,Ulcer, Peptic,Ulcers, Gastroduodenal,Ulcers, Marginal,Ulcers, Peptic
D002351 Carrageenan A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES. Carrageenin,iota-Carrageenan,kappa-Carrageenan,lambda-Carrageenan,iota Carrageenan,kappa Carrageenan,lambda Carrageenan
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000700 Analgesics Compounds capable of relieving pain without the loss of CONSCIOUSNESS. Analgesic,Anodynes,Antinociceptive Agents,Analgesic Agents,Analgesic Drugs,Agents, Analgesic,Agents, Antinociceptive,Drugs, Analgesic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000893 Anti-Inflammatory Agents Substances that reduce or suppress INFLAMMATION. Anti-Inflammatory Agent,Antiinflammatory Agent,Agents, Anti-Inflammatory,Agents, Antiinflammatory,Anti-Inflammatories,Antiinflammatories,Antiinflammatory Agents,Agent, Anti-Inflammatory,Agent, Antiinflammatory,Agents, Anti Inflammatory,Anti Inflammatories,Anti Inflammatory Agent,Anti Inflammatory Agents

Related Publications

Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
April 2008, Chemical & pharmaceutical bulletin,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
August 2005, Archiv der Pharmazie,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
September 2011, Indian journal of pharmaceutical sciences,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
February 2007, European journal of medicinal chemistry,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
December 2004, Bioorganic & medicinal chemistry letters,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
June 1983, Archiv der Pharmazie,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
January 1966, Bulletin de la Societe chimique de France,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
April 2005, Bioorganic & medicinal chemistry letters,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
February 2007, Magnetic resonance in chemistry : MRC,
Aditya Kumar Kataria, and Suroor Ahmad Khan, and Mohammad Mumtaz Alam, and Asif Husain, and Mymoona Akhtar, and Suruchi Khanna, and Rashiduddin Haider, and Rashid Haider, and Mohammad Shaquiquzzaman
July 2006, European journal of medicinal chemistry,
Copied contents to your clipboard!