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1. Choline acetyltransferase activity and [3H]quinuclidinyl benzylate-binding sites were detected in the pineal gland of normotensive Wistar-Kyoto rats and of spontaneously hypertensive rats. 2. In vitro, muscarinic activation by pilocarpine increased the pineal metabolic production of hydroxyindole derivatives up to 5-hydroxytryptamine and produced a less marked stimulation of melatonin biosynthesis. 3. Electrical field stimulation of pineal gland slices caused similar metabolic effects. 4. Muscarinic blockade with atropine inhibited the effects on hydroxyindole metabolism. 5. [3H]Quinuclidinyl benzylate-binding sites, indicative of muscarinic receptors, were more numerous, and basal 5-hydroxytryptamine and melatonin levels were higher, in the pineal gland of spontaneously hypertensive rats compared with Wistar-Kyoto rats. 6. The atropine-sensitive metabolic effects of pilocarpine and electrical field stimulation on the pineal gland were increased in spontaneously hypertensive rats compared with Wistar-Kyoto rats.
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
August 1974,
Pharmacological research communications,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
July 1978,
Japanese heart journal,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
July 1978,
Japanese heart journal,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
January 1984,
Clinical and experimental hypertension. Part A, Theory and practice,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
September 1978,
The Journal of clinical investigation,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
January 1986,
Advances in experimental medicine and biology,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
March 1977,
Biochemical pharmacology,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
August 1985,
The American journal of physiology,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
November 1971,
Saishin igaku. Modern medicine,
L M Finocchiaro, and
A Scheucher, and
A L Alvarez, and
S Finkielman, and
V E Nahmod, and
C J Pirola
November 1977,
Atherosclerosis,
