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Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents. 2012
Muthusamy Venkatraj, and
Kevin K Ariën, and
Jan Heeres, and
Jurgen Joossens, and
Jonas Messagie, and
Johan Michiels, and
Pieter Van der Veken, and
Guido Vanham, and
Paul J Lewi, and
Koen Augustyns
Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
This letter reports the synthesis and structure-activity relationship (SAR) study of a series of triazine dimers as novel antiviral agents. These compounds were obtained through a bivalent ligand approach in which two triazine moieties are covalently connected by suitable linkers. Several compounds showed submicromolar activity against wild-type HIV-1 and moderate activity against single mutant strains.
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