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The effect of degradable starch microspheres (DSM) on the cellular incorporation of 5-fluorouracil (FUra) was studied in rats with solitary liver tumours. 3H-labelled FUra [0.78 mg (6000 nmol)/kg b.wt.] was injected with saline or mixed with DSM, into the hepatic artery. Labelling of the acid soluble fraction (ASF), RNA and DNA of tumour, liver, bone marrow and small intestine was measured 60 minutes after injection. The DSM had no significant effect on the incorporation of FUra into the ASF or RNA, neither in tumour nor liver tissue. Regarding the tumour/normal tissue ratios of specific radioactivities, there was with DSM a higher tumour/liver and a higher tumour/bone marrow ratio in the ASF, indicating an increased tumour drug exposure with DSM. However, this was not accompanied by any significant increase in drug anabolism.
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
January 1990,
Selective cancer therapeutics,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
December 1986,
The Journal of pharmacy and pharmacology,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
July 2006,
World journal of gastroenterology,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
January 1985,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
January 1986,
Cancer drug delivery,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
July 1989,
The British journal of surgery,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
July 1990,
The British journal of surgery,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
January 1991,
Anticancer research,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
February 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
H Teder, and
C Erichsen, and
P I Christensson, and
P E Jönsson, and
U Stenram
December 1987,
Nuclear medicine communications,
