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To characterize the muscarinic cholinergic receptors on the endothelium of human cerebral arteries, isometric tension measurement and receptor autoradiographic studies were performed. Acetylcholine (ACh) induced dose-dependent relaxation of human cerebral arteries precontracted by 10(-5) M serotonin, with an EC50 of 1.9 +/- 0.6 X 10(-6) M (n = 7). The relaxation was abolished by 10(-5) M hemoglobin. Autoradiography, using the muscarinic antagonist [3H]propylbenzilycholine mustard, demonstrated the high density of muscarinic cholinergic receptors on the endothelial cells of human cerebral arteries, especially on the luminal surface of the endothelium. These findings suggest that ACh-induced relaxation mediated by muscarinic cholinergic receptors on the endothelium has a physiological function in human cerebral arteries.
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
January 1986,
Stroke,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
December 1991,
Brain research,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
January 1984,
European journal of respiratory diseases. Supplement,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
March 1984,
The Japanese journal of surgery,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
May 1997,
Plant molecular biology,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
March 1978,
Nature,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
August 2008,
European urology,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
May 1988,
European journal of pharmacology,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
July 2009,
Ginecologia y obstetricia de Mexico,
T Tsukahara, and
N F Kassell, and
K Hongo, and
D G Vollmer, and
H Ogawa
December 1987,
Biological psychiatry,
