-transparent.png){kind=logo}
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. 2016
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany.
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin and found that myelin lamellae are broken down into vesicular structures at the innermost region of the myelin sheath. We demonstrated that myelin basic proteins (MBP), which form a polymer in between the myelin membrane layers, are targeted in these models. Elevation of intracellular Ca(2+) levels resulted in MBP network disassembly and myelin vesiculation. We propose that the aberrant phase transition of MBP molecules from their cohesive to soluble and non-adhesive state is a mechanism triggering myelin breakdown in NMO and possibly in other demyelinating diseases.
Related Publications
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
January 1987,
Critical reviews in clinical laboratory sciences,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
September 1985,
Annals of neurology,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
January 2000,
Voprosy meditsinskoi khimii,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
October 1974,
Experimental neurology,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
October 1997,
Annals of the New York Academy of Sciences,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
July 1970,
The Histochemical journal,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
January 1992,
Critical reviews in neurobiology,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
December 2008,
Clinical immunology (Orlando, Fla.),
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
December 2013,
Biological chemistry,
Marie-Theres Weil, and
Wiebke Möbius, and
Anne Winkler, and
Torben Ruhwedel, and
Claudia Wrzos, and
Elisa Romanelli, and
Jeffrey L Bennett, and
Lukas Enz, and
Norbert Goebels, and
Klaus-Armin Nave, and
Martin Kerschensteiner, and
Nicole Schaeren-Wiemers, and
Christine Stadelmann, and
Mikael Simons
October 1977,
The New England journal of medicine,
