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Cyanide detoxification in mammals occurs, in part, by sulfur transfer by rhodanese to form the less toxic thiocyanate. Thiosulfate and nitrite are often used in combination for the treatment of cyanide intoxication. This report shows that nitrite can inhibit the rate of sulfur transfer by rhodanese in vitro. Nitrate, chloride, sulfate, and acetate were also examined as inhibitors. Inhibition by nitrite appeared to be more complex than for the other anions tested. Closer examination showed that nitrite can inactivate the sulfur-free rhodanese. Our observation leads to the suggestion that, in vivo, either rhodanese is maintained in its more stable sulfur-substituted form or cellular compartmentalization prevents inactivation by nitrite.
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
August 1975,
European journal of biochemistry,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
September 1977,
Biochemical and biophysical research communications,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
January 1988,
Journal of enzyme inhibition,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
August 1980,
Biochemical Society transactions,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
July 2007,
The AAPS journal,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
September 1956,
Lancet (London, England),
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
July 1983,
Molecular pharmacology,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
January 1973,
Journal of agricultural and food chemistry,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
December 1986,
The Journal of biological chemistry,
K Alexander, and
L R Procell, and
S D Kirby, and
S I Baskin
January 1983,
Biochimica et biophysica acta,
