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The ability of cimetidine to induce the hepatic microsomal mixed-function oxidases was investigated in rats treated orally with the drug at 3 dose levels: 10, 100 and 500 mg/kg. At the highest dose only, cimetidine stimulated the dealkylations of ethoxyresorufin, ethoxycoumarin and pentoxyresorufin but inhibited that of erythromycin and had no effect on the demethylation of dimethylnitrosamine. At the highest dose cimetidine had a small effect on the activation of Glu-P-1 to mutagens in the Ames test but induced proteins recognised in Western blots by antibodies to P450 I A1 and P450 II B1. It is concluded that cimetidine is a weak selective inducer of cytochrome P-450 forms, but at therapeutic doses its inductive effect is most unlikely to be of any clinical or toxicological consequence.
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
March 1974,
Proceedings of the National Academy of Sciences of the United States of America,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
September 1970,
Life sciences. Pt. 1: Physiology and pharmacology,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
January 1979,
Journal of agricultural and food chemistry,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
January 1976,
Biochemical pharmacology,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
March 1977,
Life sciences,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
December 1972,
Environmental research,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
December 1988,
Biochemical pharmacology,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
November 1980,
Experientia,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
January 1978,
Experimental gerontology,
C Ioannides, and
A D Rodrigues, and
A D Ayrton, and
C R Barnett, and
J Chown, and
D V Parke
May 1972,
Archives of biochemistry and biophysics,
