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Effects of synthetic compounds similar to the structure of a spider toxin were studied on the glutamate receptors in crustacean neuromuscular synapses. Two kinds of analogues, 2,4-dihydroxyphenylacetyl-asparaginyl cadaverine (C-1) and 2,4-dihydroxyphenylacetyl-asparaginyl spermine (C-2), suppressed the excitatory postsynaptic potentials in a manner similar to natural spider toxin (JSTX). The dose-response relationship showed that the relative potency of the compounds is C-1 less than C-2 less than JSTX. While the effect of JSTX was irreversible, those of C-1 and C-2 were reversible. These synthetic compounds may serve as important tools in studying the structure and function of glutamate receptors.
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
January 1983,
Advances in biochemical psychopharmacology,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
May 1992,
Brain research. Molecular brain research,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
January 1991,
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
January 1984,
Journal de physiologie,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
June 1990,
Neuroscience letters,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
January 1984,
Brain research,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
August 1987,
Brain research,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
October 1990,
Seikagaku. The Journal of Japanese Biochemical Society,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
September 1965,
Schweizerische medizinische Wochenschrift,
K Shudo, and
Y Endo, and
Y Hashimoto, and
Y Aramaki, and
T Nakajima, and
N Kawai
October 1991,
Neuroscience research,
