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A preliminary study of the distribution of the 99mTc complex of hexamethylpropylene amine oxime (HM-PAO) in 12 patients with brain neoplasms before, during, and after radiotherapy has been performed. Untreated brain tumors were found to exhibit a range of 99mTc-HM-PAO uptake, varying from areas of markedly increased isotope activity to photopenic areas, when compared to normal brain tissue. A ratio of 99mTc-HM-PAO tumor uptake to contralateral normal tissue uptake was calculated prior to and during radiotherapy. This ratio tended to return towards unity in lesions responding to therapy. A predictable alteration in whole brain 99mTc-HM-PAO uptake during radiotherapy was not demonstrated. Unlike the radiolabeled amines, 99mTc-HM-PAO localizes in primary tumors, probably indicating that its uptake mechanism is independent of non specific amine receptors. 99mTc-HM-PAO may be useful in the study of brain tumor physiology and response to therapy.
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
November 1987,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
April 1994,
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
April 1991,
La Radiologia medica,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
November 1989,
Clinical nuclear medicine,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
January 1989,
European journal of nuclear medicine,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
December 1989,
Clinical nuclear medicine,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
December 1987,
Ugeskrift for laeger,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
January 1987,
Radiography,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
March 1987,
Epilepsy research,
J W Babich, and
F Keeling, and
M A Flower, and
L Repetto, and
A Whitton, and
S Fielding, and
A Fullbrook, and
R J Ott, and
V R McCready
August 1988,
Clinical nuclear medicine,
