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The inhibitory potential of treatment with acetaminophen (AAP) and 3 different isometric forms of monoaminophenols (o-, m-, p-AP) for the development of gamma-glutamyltranspeptidase-positive (gamma-GT+) liver cell foci was examined in an in vivo short-term assay system. Rats were initially given a single intraperitoneal injection of diethylnitrosamine (DEN) and fed test compounds from week 2 until they were killed at week 6, all rats being subjected to two-thirds partial hepatectomy at week 3. All 4 compounds exerted obvious inhibition of the development of gamma-GT foci with both number and area (mm2) being reduced. AAP proved the most potent agent whereas dose-related inhibitory potential was observed within the 2 doses of p-AP treated.
Y Kurata, and
H Tsuda, and
S Tamano, and
N Ito
July 1994,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
Y Kurata, and
H Tsuda, and
S Tamano, and
N Ito
May 1987,
Cancer research,
Y Kurata, and
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N Ito
November 1990,
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Y Kurata, and
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Y Kurata, and
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Y Kurata, and
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N Ito
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Japanese journal of cancer research : Gann,
Y Kurata, and
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January 1985,
Japanese journal of cancer research : Gann,
Y Kurata, and
H Tsuda, and
S Tamano, and
N Ito
July 2005,
International journal of cancer,
Y Kurata, and
H Tsuda, and
S Tamano, and
N Ito
March 1987,
Japanese journal of cancer research : Gann,
Y Kurata, and
H Tsuda, and
S Tamano, and
N Ito
June 1988,
Japanese journal of cancer research : Gann,
