-transparent.png){kind=logo}
The peptide bond between Pro-Leu or Leu-Gly in Pro-Leu-Gly-NH2 was replaced by a CH2-NH function. The 1H and 13C n.m.r. studies demonstrated that HCl X Pro-Leu psi (CH2-NH)Gly-NH2 10 adopted a conformation in DMSO that is similar to the previously postulated beta-turn for the natural hormone. This was not the case for the other analogue. In vivo tests on 10 revealed an activity approximately equal to the natural compound and an increased toxicity.
Related Publications
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
December 1986,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
January 1983,
Methods and findings in experimental and clinical pharmacology,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
August 1999,
Bioorganic & medicinal chemistry letters,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
January 1979,
European journal of pharmacology,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
November 1982,
Pharmacology, biochemistry, and behavior,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
January 1980,
Peptides,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
August 1985,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
February 1999,
Journal of medicinal chemistry,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
July 1983,
Pharmacology, biochemistry, and behavior,
P Vander Elst, and
M Elseviers, and
E De Cock, and
M Van Marsenille, and
D Tourwé, and
G Van Binst
January 1987,
Peptides,
