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A cyclic dipeptide in which L-Ala-Gly was cyclized with epsilon-aminocaproic acid has been synthesized as a model for a beta-bend. Its conformational properties have been examined by means of conformational energy calculations and nuclear magnetic resonance, infrared, Raman, and circular dichroism spectroscopy in various solvents. These calculations and experiments suggest that a type II beta-bend exists in the Ala-Glymoiety, with an NH...O = C hydrogen bond in the epsilon-aminocaproic acid portion of the molecule, and that the molecule adopts a unique conformation in solution. In contrast, an open-chain analog of this compound exists in solution as an ensemble of conformations but with a significant amount of a type II beta-bend structure in the ensemble.
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
January 1985,
International journal of peptide and protein research,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
April 1971,
Journal of theoretical biology,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
March 2003,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
October 1971,
The Journal of experimental biology,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
January 2001,
Journal of the American Chemical Society,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
August 1992,
Proceedings of the National Academy of Sciences of the United States of America,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
March 1975,
Journal of molecular biology,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
February 1982,
International journal of peptide and protein research,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
November 1986,
Biophysical chemistry,
R Deslauriers, and
S J Leach, and
F R Maxfield, and
E Minasian, and
J R McQuie, and
Y C Meinwald, and
G Némethy, and
M S Pottle, and
I D Rae, and
H A Scheraga, and
E R Stimson, and
J W Van Nispen
June 1982,
Hormones and behavior,
