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Conformational analyses on four cyclic model peptides of the beta-bend, cyclo(L- or D-Phe-L-Pro-epsilon-aminocaproyl(Aca] and cyclo(L-Pro-L- or D-Phe-Aca), were carried out both experimentally and theoretically. Cyclo(D-Phe-L-Pro-Aca) was shown to exist as a single conformer taking the type II' beta-bend. The comparison of its CD spectra with those of cyclo(L-Ala-L-Ala-Aca) revealed that type I and II' beta-bends, both with alpha-helix-like CD spectra, can be distinguished. Cyclo(L-Phe-L-Pro-Aca) was shown to exist as a single conformer with a cis L-Phe-L-Pro peptide bond, taking the type VI beta-bend. Its CD spectrum has thus been observed for the first time for the bend containing a cis peptide bond. Cyclo(L-Pro-L-Phe-Aca) was shown to exist as a mixture of two conformers, the major one taking the type I beta-bend with a trans Aca-L-Pro peptide bond and the minor one with a cis Aca-L-Pro peptide bond. Cyclo(L-Pro-D-Phe-Aca) was suggested to exist as a mixture of two conformers, the major one taking the type II beta-bend with a trans Aca-L-Pro peptide bond and the minor one with a cis Aca-L-Pro peptide bond.
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
February 1982,
International journal of peptide and protein research,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
January 1985,
International journal of peptide and protein research,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
February 1993,
International journal of peptide and protein research,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
December 1992,
Biopolymers,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
April 1990,
Acta crystallographica. Section B, Structural science,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
September 1973,
Journal of the American Chemical Society,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
August 1989,
International journal of peptide and protein research,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
September 2002,
Applied and environmental microbiology,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
September 1988,
International journal of peptide and protein research,
H Mizuno, and
S Lee, and
H Nakamura, and
Y Kodera, and
T Kato, and
N Go, and
N Izumiya
October 1991,
International journal of peptide and protein research,
